This seems to me to resonate closely with Latour’s post-Prometheanism. I dare to make the connection as I think it reveals yet another nuance to the meaning of resisting (over)reduction.
One practical implication of adopting an ‘humble’ approach is the capacity to take full responsibility over outcomes, including failures. Humility confers the power to expect, therefore detect, therefore admit defeats. Reductionism, on the other hand, faces structural difficulties in fitting evidence of failure within its paradigm of linear progression. From this angle, it would seem that resisting reduction is something reduction itself may need the most.
Does this make any sense?